Congratulations to Xin Jingrui, Lu Xue, their paper entitled 'Fluorinated Organic Polymers for Cancer Drug Delivery.' has been published in Adv. Mater.
In
the realm of cancer therapy, the spotlight is on nanoscale pharmaceutical
delivery systems, especially polymer-based nanoparticles, for their enhanced
drug dissolution, extended presence in the bloodstream, and precision targeting
achieved via surface engineering. Leveraging the amplified permeation and
retention phenomenon, these systems concentrate therapeutic agents within tumor
tissues. Nonetheless, the hurdles of systemic toxicity, biological barriers,
and compatibility with living systems persist. Fluorinated polymers,
distinguished by their chemical idiosyncrasies, are poised for extensive
biomedical applications, notably in stabilizing drug metabolism, augmenting
lipophilicity, and optimizing bioavailability. Material science heralds the
advent of fluorinated polymers that, by integrating fluorine atoms, unveil a
suite of drug delivery merits: the hydrophobic traits of fluorinated alkyl
chains ward off lipid or protein disruption, the carbon–fluorine bond's
stability extends the drug's lifecycle in the system, and a lower alkalinity
coupled with a diminished ionic charge bolsters the drug's ability to traverse
cellular membranes. This comprehensive review delves into the utilization of
fluorinated polymers for oncological pharmacotherapy, elucidating their
molecular architecture, synthetic pathways, and functional attributes,
alongside an exploration of their empirical strengths and the quandaries they
encounter in both experimental and clinical settings.
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